- Title
- Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
- Creator
- Ferreira, Manuel A.; Gamazon, Eric R.; Al-Ejeh, Fares; Aittomäki, Kristiina; Andrulis, Irene L.; Anton-Culver, Hoda; Arason, Adalgeir; Arndt, Volker; Aronson, Kristan J.; Arun, Banu K.; Asseryanis, Ella; Azzollini, Jacopo; Balmaña, Judith; Barnes, Daniel R.; Barrowdale, Daniel; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bialkowska, Katarzyna; Forbes, John; John, EM; Johnson, N; Joseph, V; Karlan, BY; Khusnutdinova, E; Kiiski, J; Ko, Y-D; Jones, ME; Konstantopoulou, I; Kristensen, VN; Laitman, Y; Lambrechts, D; Lazaro, C; Leslie, G; Lester, J; Lesueur, F; Lindstrom, S; Long, J; Loud, JT; Lubinski, J; Makalic, E; Mannermaa, A; Manoochehri, M; Margolin, S; Maurer, T; Mavroudis, D; McGuffog, L; Meindl, A; Menon, U; Michailidou, K; Miller, A; Montagna, M; Moreno, F; Moserle, L; Mulligan, AM; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Nevelsteen, I; Nielsen, FC; Nikitina-Zake, L; Nussbaum, RL; Offit, K; Olah, E; Olopade, O; Olsson, H; Osorio, A; Papp, J; Park-Simon, T-W; Parsons, MT; Pedersen, IS; Peixoto, A; Peterlongo, P; Pharoah, PDP; Plaseska-Karanfilska, D; Poppe, B; Presneau, N; Radice, P; Rantala, J; Rennert, G; Risch, HA; Saloustros, E; Sanden, K; Sawyer, EJ; Schmidt, MK; Schmutzler, RK; Sharma, P; Shu, X-O; Simard, J; Singer, CF; Soucy, P; Southey, MC; Spinelli, JJ; Spurdle, AB; Stone, J; Swerdlow, AJ; Tapper, WJ; Taylor, JA; Teixeira, MR; Terry, MB; Teule, A; Thomassen, M; Thoene, K; Thull, DL; Tischkowitz, M; Toland, AE; Torres, D; Truong, T; Tung, N; Vachon, CM; van Asperen, CJ; van den Ouweland, AMW; van Rensburg, EJ; Vega, A; Viel, A; Wang, Q; Wappenschmidt, B; Weitzel, JN; Wendt, C; Winqvist, R; Blomqvist, Carl; Yang, XR; Yannoukakos, D; Ziogas, A; Kraft, P; Antoniou, AC; Zheng, W; Easton, DF; Milne, RL; Beesley, J; Chenevix-Trench, G; Bogdanova, N; Arnold, N; Auber, B; Bogdanova-Markov, N; Borde, J; Caliebe, A; Ditsch, N; Dworniczak, B; Engert, S; Faust, U; Gehrig, A; Bojesen, SE; Hahnen, E; Hauke, J; Hentschel, J; Herold, N; Honisch, E; Just, W; Kast, K; Larsen, M; Lemke, J; Huu, PN; Bolla, MK; Niederacher, D; Ott, C-E; Platzer, K; Pohl-Rescigno, E; Ramser, J; Rhiem, K; Steinemann, D; Sutter, C; Varon-Mateeva, R; Wang-Gohrke, S; Borg, A; Weber, BHF; Prieur, F; Pujol, P; Sagne, C; Sevenet, N; Sobol, H; Sokolowska, J; Stoppa-Lyonnet, D; Venat-Bouvet, L; Adlard, J; Brauch, H; Ahmed, M; Barwell, J; Brady, A; Brewer, C; Cook, J; Davidson, R; Donaldson, A; Eason, J; Eeles, R; Evans, DG; Brenner, H; Gregory, H; Hanson, H; Henderson, A; Hodgson, S; Izatt, L; Kennedy, MJ; Lalloo, F; Miller, C; Morrison, PJ; Ong, K-R; Broeks, A; Perkins, J; Porteous, ME; Rogers, MT; Side, LE; Snape, K; Walker, L; Harrington, PA; Heemskerk-Gerritsen, BAM; Rookus, MA; Seynaeve, CM; Burwinkel, B; van der Baan, FH; van der Hout, AH; van der Kolk, LE; van der Luijt, RB; van Deurzen, CHM; van Doorn, HC; van Engelen, K; van Hest, L; van Os, TAM; Verhoef, S; Caldes, T; Vogel, MJ; Wijnen, JT; Miron, A; Kapuscinski, M; Bane, A; Ross, E; Buys, SS; Conner, TA; Balleine, R; Baxter, R; Caligo, MA; Braye, S; Carpenter, J; Dahlstrom, J; Lee, SC; Marsh, D; Morey, A; Pathmanathan, N; Simpson, P; Spigelman, A; Campa, D; Wilcken, N; Yip, D; Campbell, I; Canzian, F; Carter, J; Carter, BD; Castelao, JE; Chang-Claude, J; Chanock, SJ; Christiansen, H; Chung, WK; Claes, KBM; Clarke, CL; Couch, FJ; Cox, A; Cross, SS; Czene, K; Daly, MB; de la Hoya, M; Dennis, J; Devilee, P; Diez, O; Doerk, T; Dunning, AM; Dwek, M; Eccles, DM; Ejlertsen, B; Ellberg, C; Engel, C; Eriksson, M; Fasching, PA; Fletcher, O; Flyger, H; Friedman, E; Frost, D; Gabrielson, M; Gago-Dominguez, M; Ganz, PA; Gapstur, SM; Garber, J; Garcia-Closas, M; Garcia-Saenz, JA; Gaudet, MM; Giles, GG; Glendon, G; Godwin, AK; Goldberg, MS; Goldgar, DE; Gonzalez-Neira, A; Greene, MH; Gronwald, J; Guenel, P; Haiman, CA; Hall, P; Hamann, U; He, W; Heyworth, J; Hogervorst, FBL; Hollestelle, A; Hoover, RN; Hopper, JL; Hulick, PJ; Humphreys, K; Imyanitov, EN; Isaacs, C; Jakimovska, M; Jakubowska, A; James, PA; Janavicius, R; Jankowitz, RC
- Relation
- Nature Communications Vol. 10, no. 1741
- Publisher Link
- http://dx.doi.org/10.1038/s41467-018-08053-5
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2019
- Description
- Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.
- Subject
- genome-wide association studies (GWAS); breast cancer; risk loci; target genes; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1453065
- Identifier
- uon:44579
- Identifier
- ISSN:2041-1723
- Rights
- © Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
- Reviewed
- Hits: 115676
- Visitors: 115692
- Downloads: 104
Collections
Goal 3: Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 3 MB | Adobe Acrobat PDF | View Details Download |